Study on the correlation between eosinophils and chronic rhinosinusitis with nasal polyps in Xinjiang region of China / 中华耳鼻咽喉头颈外科杂志

Objective: To explore the correlation between eosinophils (Eos) and the incidence of chronic sinusitis with nasal polyps (CRSwNP) in Xinjiang region of China by comparing the proportion of inflammatory cells in the pathological tissues and peripheral blood. Methods: Retrospective analysis was performed on 582 patients with CRSwNP who underwent endoscopic nasal surgery in the First Affiliated Hospital of Xinjiang Medical University from January 2012 to March 2018, including 367 males and 215 females, aged (45.5±13.4) years (x¯±s). Patients were divided into groups according to demographic characteristics, recurrence and complication of allergic rhinitis (AR). Preoperative blood routine and postoperative pathological section data of nasal polyps were collected to compare the ratio of inflammatory cells in pathological tissue and the ratio of peripheral blood Eos in each group. The correlation between the proportion of inflammatory cells in the pathological tissue of nasal polyps and the recurrence of CRSwNP was analyzed, as well as the distribution of (eosCRSwNP) in Uygur and Han CRSwNP patients in Xinjiang region. Statistical analysis was performed by SPSS 19.0 software. Results: Compared with non-recurrent CRSwNP patients, the ratio of Eos in nasal polyp tissue and peripheral blood was increased significantly, (Z value was -3.142 and -2.344, respectively, both P<0.05). Compared with CRSwNP patients without AR, the ratio of Eos in nasal polyps and peripheral blood was also increased significantly in patients with AR (Z value was -6.664 and -4.520, respectively, both P<0.05). There was a positive correlation between tissue Eos and CRSwNP recurrence (r=0.130, P=0.002). The majority of CRSwNP patients were both eosCRSwNP in Uygur and Han ethnic groups. Conclusions: Eos is associated with the recurrence of CRSwNP in Xinjiang region, and eosCRSwNP is the dominant factor in both Uygur and Han patients.

Nasal polyposis in cystic fibrosis: follow-up of children and adolescents for a 3-year period / Polipose nasal em fibrose cística: seguimento em crianças e adolescentes durante um período de 3 anos

Abstract Introduction: Nasal polyposis is often found in patients with cystic fibrosis. Objective: To assess the incidence of nasal polyposis, the response to medical treatment, recurrence and the need for surgical intervention in children and adolescents with cystic fibrosis during a three-year follow-up. Methods: Clinical symptoms (pulmonary, pancreatic insufficiency, malnutrition, nasal obstruction), two positive sweat chloride tests, and genotype findings in 23 patients with cystic fibrosis were analyzed. All patients underwent nasal endoscopy every 12 months from January 2005 to December 2007, to assess the presence and grade of Nasal Polyps. Nasal polyposis, when present, were treated with topical corticosteroids for 6-12 months, with progress being evaluated within the 3 years of follow-up. Results: In the first evaluation, nasal polyposis was diagnosed in 30.43% of patients (3 bilateral and 4 unilateral), recurrent pneumonia in 82.6%, pancreatic insufficiency in 87%, and malnutrition in 74%. The presence of nasal polyposis was not associated with chloride values in the sweat, genotype, clinical signs of severity of cystic fibrosis, or nasal symptoms. In the three-year period of follow up, 13 patients (56.52%) had at least one event of polyposis, with the youngest being diagnosed at 32 months of age. Only one patient underwent surgery (polypectomy), and there was one diagnosis of nasopharyngeal carcinoma. Conclusion: The study showed a high incidence of nasal polyposis. Monitoring through routine endoscopy in patients with cystic fibrosis, even in the absence of nasal symptoms, is highly recommended. The therapy with topical corticosteroids achieved good results. Thus, an interaction between pediatricians and otolaryngologists is necessary.

Resumo Introdução: A polipose nasal é frequentemente encontrada em pacientes portadores de fibrose cística. Objetivo: Avaliar a incidência de polipose nasal, a resposta ao tratamento clínico, a recorrência e a necessidade de intervenção cirúrgica em crianças e adolescentes com fibrose cística durante um seguimento de 3 anos. Método: Os sintomas clínicos (pulmonar, insuficiência pancreática, desnutrição, obstrução nasal), duas pesquisas de cloro no suor positivas e genótipo de 23 pacientes com fibrose cística foram descritos. Todos os pacientes foram submetidos à endoscopia nasal a cada 12 meses de janeiro de 2005 a dezembro de 2007, para avaliação de presença e grau de polipose nasal. A polipose nasal, quando presente, foi tratada com corticosteroide tópico de 6 a 12 meses e avaliada a evolução nos 3 anos de seguimento. Resultados: Na primeira avaliação, a polipose nasal foi diagnosticada em 30,43% dos pacientes (três bilaterais e quatro unilaterais), pneumonia recorrente em 82,6%, insuficiência pancreática em 87% e a desnutrição em 74%. A presença de polipose nasal não se associou aos valores de cloro no suor, genótipo, sinais clínicos de gravidade da fibrose cística ou sintomas nasais. Nos três anos de seguimento, 13 pacientes (56,52%) apresentaram pelo menos um evento de polipose, o mais jovem foi diagnosticado aos 32 meses. Apenas um paciente foi submetido à cirurgia (polipectomia) e houve um diagnóstico de carcinoma da nasofaringe. Conclusão: O estudo mostrou alta incidência de polipose nasal. O acompanhamento por meio de exames endoscópicos de rotina em pacientes fibrocisticos, mesmo na ausência de sintomas nasais, é altamente recomendado. A terapia com corticoide tópico mostrou bons resultados. Assim, faz-se necessária a interação entre pediatras e otorrinolaringologistas.

Resultados de la cirugía endoscópica nasosinusal en la poliposis nasosinusal, con microdesbridador y sin él / Results of the nasosinusal endoscopic surgery in nasosinusal polyposis with and without micro defibrillator

INTRODUCCIÓN. La poliposis nasal es una enfermedad multifactorial con prevalencia en la población general del 2 al 5 por ciento. Fue objetivo de este estudio comparar los resultados quirúrgicos en 60 pacientes con poliposis nasosinusal, operados con microdesbridador y sin él. MÉTODOS. Se analizaron 60 pacientes operados entre el 2002 y el 2006. Se estudiaron factores relacionados, como asma, intolerancia al ácido acetilsalicílico y alergia. Fueron consideradas las cirugías previas, endoscópicas o convencionales, así como las complicaciones menores y mayores derivadas de éstas. Se revisaron los casos que no se lograron controlar con tratamiento médico. RESULTADOS. Los resultados globales fueron satisfactorios: a los 2 años 29 pacientes (48,3 por ciento) estaban asintomáticos, 45 (75 por ciento) con las fosas libres de pólipos, 11 (18,3 por ciento) con recidiva controlada con tratamiento médico y hubo que reintervenir solo a 2 pacientes (3,3 por ciento). El número de complicaciones permaneció muy por debajo del nivel razonable; hubo solo 2 (3,3 por ciento) complicaciones mayores: un hematoma periorbitario y una lesión de lámina papirácea. CONCLUSIONES. Las afecciones inflamatorias nasosinusales, y en especial la poliposis nasal, se benefician con un tratamiento quirúrgico endoscópico. La experiencia y el uso de instrumental motorizado (microdesbridador) han mejorado aún más los resultados de esta técnica(AU)

INTRODUCTION. Nasal polyposis is a multifactor disease with prevalence in general population from 2 to 5 percent. The objective of present paper was to compare the surgical results in 60 patients with nasosinusal polyposis operated on with and without micro-defibrillator. METHODS. Sixty patients operated on between 2002 and 2006. The related factors were studied including asthma, acetylsalicylic acid and allergy. Previous, endoscopic or conventional surgeries were considered as well as the minor and major complications derived from it. The non-controlled cases with medical treatment were reviewed. RESULTS. The overall results were satisfactory: at two years 29 patients (48,3 percent) were asymptomatic, 45 (75 percent) with fossae free of polypi, 11 (18,3 percent) with relapse controlled by medical treatment and only a reintervention in two patients (3,3 percent). The figure of complications remained very low of the reasonable level; there was only 2 (3,3 percent) (major complications): a periorbital hematoma and a lesion of papyraceous plate. CONCLUSIONS. The nasosinusal affections and specially the nasal polyposis to do well out the endoscopic surgical treatment. The experience and the use of motorized instrumental (micro- defibrillator) have improved even more the results of this technique(AU)

Unilateral ethmoidal polyps

To know the etiology and incidence of unilateral ethmoidal polyps. Descriptive. ENT department Allied Hospital Faisalabad. From Jan 2007 to June 2009. The patients were admitted through ENT out patient department. The data was collected on the basis of history, physical examination, investigations, management and follow up. Out of 200 patients between 05 years to 60 years of age suffering from ethmoidal polyps the incidence of unilateral ethmoidal polyps was 35% and that of bilateral ethmoidal polyps was 65%. The 57% of patients having unilateral ethmoidal polyps were male and 43% female. The highest incidence of unilateral ethmoidal polyps was seen during second decade of life 43%.The incidence of unilateral ethmoidal polyps and bilateral ethmoidal polyps was 1.6 and 03 cases per month respectively. The most common presenting symptom was unilateral nasal obstruction [100%] in cases of unilateral ethmoidal polyps. The most common associated disease in patients with unilateral ethmoidal polyps was deflected nasal septum [71%]. Transantral ethmoidectomy was carried out in majority of patients [43%]. The most common etiology held to be responsible for unilateral ethmoidal polyps was Vasomotor rhinitis [57%]. The unilateral ethmoidal polyps are not uncommon in young adults and the etiological factors are same as that for bilateral ethmoidal polyps

Comorbidities in severe asthma: frequency of rhinitis, nasal polyposis, gastroesophageal reflux disease, vocal cord dysfunction and bronchiectasis

OBJECTIVES: Severe asthma is found in approximately 10 percent of patients with asthma. Some factors associated with worse asthma control include rhinitis, gastroesophageal reflux disease, vocal cord dysfunction (VCD), nasal polyposis and bronchiectasis. Therefore, we evaluated the prevalence of these illnesses in patients with severe asthma. METHODS: We conducted a retrospective analysis of data obtained from electronic medical records of patients with severe asthma between January 2006 and June 2008. Symptoms of rhinitis and gastroesophageal reflux disease were evaluated as well as intolerance to nonsteroidal anti-inflammatory drugs. We evaluated the results of esophagogastroduodenoscopy, videolaryngoscopy and CT scans of the chest in order to confirm gastroesophageal reflux disease, nasal polyposis, vocal cord dysfunction and bronchiectasis. RESULTS: We evaluated 245 patients. Rhinitis symptoms were present in 224 patients (91.4 percent); 18 (7.3 percent) had intolerance to nonsteroidal anti-inflammatory drugs, and 8 (3.3 percent) had nasal polyposis. Symptoms of gastroesophageal reflux disease were reported for 173 (70.6 percent) patients, although the diagnosis of gastroesophageal reflux disease was confirmed based on esophagogastroduodenoscopy or laryngoscopy findings in just 58 (33.6 percent) patients. Vocal cord dysfunction was suspected in 16 (6.5 percent) and confirmed through laryngoscopy in 4 (1.6 percent). The patient records provided CT scans of the chest for 105 patients, and 26 (24.8 percent) showed bronchiectasis. DISCUSSION: Rhinitis and gastroesophageal reflux disease were the most common comorbidities observed, in addition to bronchiectasis. Therefore, in patients with severe asthma, associated diseases should be investigated as the cause of respiratory symptoms and uncontrolled asthma.

Incidência e evolução da polipose nasal em crianças e adolescentes com fibrose cística / Incidence and evolution of nasal polyps in children and adolescents with cystic fibrosis

A polipose nasal é manifestação clínica de alerta para investigação de fibrose cística (FC). OBJETIVO: Avaliar incidência de pólipos nasais em crianças e adolescentes com FC, sua associação com idade, sexo, sintomas clínicos, achados laboratoriais e genótipo, e sua evolução com corticoterapia tópica. CASUÍSTICA E MÉTODOS: Foram avaliados sintomas clínicos, níveis de cloro no suor e mutações genéticas de 23 pacientes com FC. A polipose nasal foi investigada por exame endoscópico e quando presente, o paciente recebeu 6 meses de tratamento com corticosteróide tópico e foi realizada nova endoscopia depois. Para análise estatística utilizou-se média, desvio padrão e Teste de Fisher. RESULTADOS: 39,1 por cento dos pacientes apresentaram polipose nasal (cinco bilateral, quatro unilateral), todos com mais de seis anos, 82,6 por cento, pneumonias recorrentes, 87 por cento, insuficiência pancreática e 74 por cento, desnutrição. Não houve associação entre polipose e nível de cloro no suor, genótipo, fenótipo clínico e sintomas nasais. Houve melhora da polipose com tratamento clínico em sete pacientes, com regressão completa em seis. CONCLUSÃO: O estudo mostrou elevada incidência de polipose em crianças com FC, sendo encontrada em todos os espectros de gravidade clínica, mesmo na ausência de sintomas nasais. O tratamento com corticosteróide tópico mostrou-se eficaz. A interação de pneumopediatra e do otorrinolaringologista é fundamental para diagnóstico e seguimento.

Nasal polyps are a clinical sign of alert for investigating Cystic Fibrosis (CF). AIMS: To study the incidence of nasal polyps in children and adolescents with cystic fibrosis, its possible association with age, gender, clinical manifestations, genotype and sweat chlorine level, and its evolution with topical steroid therapy. METHODS: Clinical symptoms, sweat chlorine level and genotype were studied in 23 cystic fibrosis patients. Nasal polyps were diagnosed by nasal endoscopy and treated with topical steroids during 6 months, followed by a second nasal endoscopy. Fisher test was used for statistical analysis. RESULTS: Nasal polyps were found in 39.1 percent of the patients (five bilateral, four unilateral), all older than six years, recurrent pneumonia in 82.6 percent, pancreatic insufficiency in 87 percent and malnutrition in 74 percent. No association was seen between nasal polyps and sweat chlorine level, genotype, clinical sings of severity and nasal symptoms. Seven patients improved in their nasal polyps with topical steroids, six showed complete resolution. CONCLUSION: The study showed a high incidence of nasal polyps in older children, who span the entire range of clinical severity, even in the absence of clinical nasal symptoms. Topical steroid therapy showed good results. An interaction among pediatricians and otolaryngologists is necessary for diagnosis and follow-up.

Análise epidemiológica de pacientes com polipose nasal / Epidemiological analysis in patients with nasal polyps

A polipose nasal possui alta morbidade. Sua sintomatologia está relacionada à alteração da função nasossinusal. Avaliar a sintomatologia dos pacientes com polipose nasal e comorbidades relacionadas, como asma e intolerância a aspirina, além de fazer uma revisão sobre aspectos pertinentes à polipose nasal...

Nasal polyps cause considerable morbidity and symptoms are related to nasosinusal dysfunction. The prospective study has the objective to analyse the symptoms in patients with nasal polyps and the comorbidities that are often related to nasal polyps such as asthma and aspirin intolerance...

Role of allergy in nasal polyps of Thai patients.

As distinct from many countries, allergy in Thailand is of the perennial type which may play a role in the formation of nasal polyps. Forty consecutive patients with nasal polyps and 30 normal subjects as control were studied at the Allergy Clinic, Department of Otolaryngology, Pramongkutklao Hospital. A positive clinical history and skin allergy testing are diagnostic criteria for allergy. In the nasal polyps group, these were 28 males and 12 females, aged between 12-65 years, with an average age of 38.5 years. In the control group, there were 18 males and 12 females, aged between 15-53 yeas, with an average age of 34 years. All had received prick skin testing with 6 common aeroallergens. The prick skin test was considered positive when the wheal was > or = 3 mm with surrounding erythema. Twenty-four of 40 patients (60%) with nasal polyps had a positive prick skin test, while 6 in the 30 control cases (20%) had a positive prick skin test. This difference was statistically significant (P = 0.0019), Odd's ratio = 6.0 which means allergic persons were 6 times more prone to have polyps form than normal persons.